Make the most of it while you can!
Life is short and very unpredictable. We need to make the most of every opportunity we are given. Whether it be climbing a mountain, going on a dream holiday, eating in fancy restaurants or just spending more time with your family. Don't let these opportunities pass you by. We are not here forever sadly so let's make the most of what we have and what we want to do while we can.
I've never been one to take things too seriously except when at work that obviously needs to be taken seriously. But out of work I like to have fun, and throw caution to the wind and say "what the hell, lets go for it I may not be here tomorrow?" I try and say yes to most things because saying no is I feel denying myself an opportunity I may regret I didn't take. Unless that opportunity is of course 'stick your head through this glass window'! That type of opportunity I can happily live without! Try not if you can to deny yourself anything in life.
A work colleague of mine once told me he never refused to spend a single moment with his grandchildren because that may be the last time he would see them potentially. Once that you say no you will never get that opportunity again and you never know what that opportunity may lead to?